Humate-P

Generic Name: antihemophilic factor (factor VIII) (injectable) (an TEE hee moe FIH lick FAC tor)
Brand Names: Advate rAHF-PFM, Alphanate, Helixate, Helixate FS, Hemofil-M, Humate-P, Hyate C, Koate-DVI, Koate-HP, Kogenate, Kogenate FS, Monarc-M, Monoclate-P, Recombinate, Refacto

What is the most important information I should know about antihemophilic factor (factor VIII)?

Some forms of antihemophilic factor (factor VIII) are made from human plasma (part of the blood) and may contain infectious agents (e.g., viruses) that can cause disease. Although antihemophilic factor (factor VIII) is screened, tested, and treated to reduce the possibility that it carries an infectious agent, it can still potentially transmit disease. Discuss with your doctor the risks and benefits of using antihemophilic factor (factor VIII) from human sources.

Some viruses, such as parovovirus B19 and hepatitis A, may be more difficult to identify or remove from antihemophilic factor (factor VIII). Parovovirus B19 may more seriously affect pregnant women and those with poor immune systems. Symptoms of parovovirus B19 infection include fever, chills, runny nose, and drowsiness followed about 2 weeks later by a rash and joint pain. Symptoms of hepatitis A may include several days to weeks of poor appetite, tiredness, and low-grade fever followed by nausea, vomiting, and pain in the belly. Dark-colored urine and yellowing of the skin or whites of the eyes may also occur. Contact your doctor if you develop any of these symptoms after treatment with antihemophilic factor (factor VIII).

Carry or wear identification that will alert others that you have hemophilia or another blood clotting disorder in the case of an emergency.

Tell your doctor and dentist that you have hemophilia or another blood clotting disorder before having surgery or other invasive procedures.

What is antihemophilic factor (factor VIII)?

Antihemophilic factor (factor VIII) is a natural protein, normally present in the blood that helps blood to clot. A deficiency of factor VIII is the cause of hemophilia A.

Antihemophilic factor (factor VIII) is used to treat or prevent bleeding in people with hemophilia A.

Antihemophilic factor (factor VIII) may also be used for purposes other than those listed here.

What should I discuss with my healthcare provider before using antihemophilic factor (factor VIII)?

Do not use antihemophilic factor (factor VIII) without first talking to your doctor if you have

had an unusual or allergic reaction to this medication, a similar medication, a human or animal (cow, hamster, mouse, or pig) protein, dyes, additives, or preservatives;
hardening of the arteries;
severe injury or infection; or
other bleeding or blood clotting disorders.

You may not be able to use antihemophilic factor (factor VIII) or you may require a dosage adjustment or special monitoring during treatment.

Antihemophilic factor (factor VIII) is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Do not use antihemophilic factor (factor VIII) without first talking to your doctor if you are pregnant.

It is not known whether antihemophilic factor (factor VIII) could be harmful to a nursing baby. Do not use antihemophilic factor (factor VIII) without first talking to your doctor if you are breast-feeding a baby.

How should I use antihemophilic factor (factor VIII)?

Antihemophilic factor (factor VIII) will be administered by intravenous (into a vein) injection by a healthcare provider.

Your doctor may want you to have blood tests or other medical evaluations during treatment with antihemophilic factor (factor VIII) to monitor progress and side effects.

Carry or wear identification that will alert others that you have hemophilia or another blood clotting disorder in the case of an emergency.

Your healthcare provider will store antihemophilic factor (factor VIII) as directed by the manufacturer.

If you are using antihemophilic factor (factor VIII) at home, your doctor or healthcare provider will give you detailed instructions on how to administer and store the medication.

What happens if I miss a dose?

Contact your doctor if a dose of antihemophilic factor (factor VIII) is missed.

What happens if I overdose?

Seek emergency medical attention if an overdose of antihemophilic factor (factor VIII) is suspected.

What should I avoid while using antihemophilic factor (factor VIII)?

Tell your doctor and dentist that you have hemophilia or another blood clotting disorder before having surgery or other invasive procedures.

What are the possible side effects of antihemophilic factor (factor VIII)?

If you experience any of the following serious side effects, contact your healthcare provider immediately or seek emergency medical attention:

an allergic reaction (shortness of breath; wheezing; tightness of the chest; closing of the throat; hives; swelling of the lips, face, or tongue; hives or rash; dizziness or fainting); or
fever;
nausea or vomiting;
increased heart rate;
decreased blood pressure (may result in dizziness or fainting);
difficulty breathing, chest pain, or cough; or
pain, redness, or swelling at the injection site.

Other, less serious side effects may be more likely to occur. Continue to use antihemophilic factor (factor VIII) and talk to your doctor if you experience

headache; or
flushing.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect antihemophilic factor (factor VIII)?

Other drugs that affect bleeding or blood-clotting processes may interact with antihemophilic factor (factor VIII) resulting in dangerous side effects and/or altered effectiveness. Do not take any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, without first talking to your doctor during treatment with antihemophilic factor (factor VIII).

Where can I get more information?

Your pharmacist has additional information about antihemophilic factor (factor VIII) written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.