oxacillin

(ox a SILL in)
Bactocill

What is the most important information I should know about oxacillin?

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Take all of the oxacillin that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.

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Do not break, chew, open, or crush the capsules. Swallow them whole.

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Oxacillin may decrease the effectiveness of birth control pills. Use a second method of birth control while taking oxacillin to protect against pregnancy.

What is oxacillin?

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Oxacillin is an antibiotic in the class of drugs called penicillins. It fights bacteria in your body.

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Oxacillin is used to treat many different types of bacterial infection, especially those caused by staphylococcus bacteria ("staph" infections).

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Oxacillin may also be used for purposes other than those listed in this medication guide.

Who should not take oxacillin?

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If you have ever had an allergic reaction to another penicillin or to a cephalosporin, do not take oxacillin unless your doctor is aware of your allergy and monitors your therapy.

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Before taking this medication, tell your doctor if you have kidney disease or infectious mononucleosis. You may not be able to take oxacillin because of an increased risk of side effects.

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If you are a diabetic, some glucose urine tests may give false positive results while you are taking oxacillin.

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Oxacillin is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not, however, take this medication without first talking to your doctor if you are pregnant.

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Oxacillin passes into breast milk. Rarely, oxacillin may cause a yeast infection, diarrhea, or allergic reaction in a nursing infant, although no serious harm is expected. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take oxacillin?

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Take oxacillin exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

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Take each dose with a full glass of water.

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Take oxacillin on an empty stomach 1 hour before or 2 hours after meals.

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Oxacillin should be taken at evenly spaced intervals throughout the day and night to keep the level in your blood high enough to treat the infection.

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Do not crush, chew, or open the capsules. Swallow them whole.

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To ensure that you get the correct dosage, measure the liquid form of oxacillin with a dose-measuring spoon or cup, not a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one. Shake the suspension well before measuring a dose.

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Take all of the oxacillin that has been prescribed for you even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated.

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Store the capsules at room temperature and store the suspension in the refrigerator for longer use. The suspension is good for 14 days if it is stored in the refrigerator. Throw away any unused liquid after this amount of time.

What happens if I miss a dose?

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Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.

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If you have only missed one dose, you can take the rest of your scheduled doses for the day at evenly spaced intervals.

What happens if I overdose?

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Seek emergency medical attention.

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Symptoms of an oxacillin overdose include muscle spasms or weakness, pain or twitching, pain in the fingers or toes, loss of feeling in the fingers or toes, seizures, confusion, coma, and agitation.

What should I avoid while taking oxacillin?

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Alcohol may irritate your stomach if taken with oxacillin, so use it moderation.

What are the possible side effects of oxacillin?

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If you experience any of the following serious side effects, stop taking oxacillin and seek emergency medical attention:

an allergic reaction (shortness of breath; closing of your throat; hives; swelling of your lips, face, or tongue; rash; or fainting);

seizures;

severe watery diarrhea and abdominal cramps; or

unusual bleeding or bruising.

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Other, less serious side effects may be more likely to occur. Continue to take oxacillin and talk to your doctor if you experience

mild nausea, vomiting, diarrhea, or abdominal pain;

white patches on the tongue (thrush/yeast infection);

itching or discharge of the vagina (vaginal yeast infection); or

black, "hairy" tongue or sore mouth or tongue.

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Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect oxacillin?

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Some drugs may decrease the effects of oxacillin and prevent it from properly treating your infection. Before taking oxacillin, tell your doctor if you are taking any of the following drugs:

cholestyramine (Questran) or colestipol (Colestid); or

another antibiotic (for the same or for a different infection) such as erythromycin (Ery-Tab, E-Mycin, E.E.S., others), tetracycline (Sumycin, others), minocycline (Minocin), doxycycline (Doryx, Vibramycin, others), or any other.

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Oxacillin may decrease the effectiveness of birth control pills. Use a second method of birth control while taking oxacillin to protect against pregnancy.

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Oxacillin increases the effects of methotrexate, and you may need a dose adjustment during therapy with oxacillin.

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Oxacillin also increases the side effects of allopurinol (Zyloprim) and may cause a rash.

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Probenecid (Benemid) increases the effects of oxacillin. These drugs may be used together for this purpose; however, be sure your doctor is aware if you are taking probenecid. You may need a lower dose of oxacillin.

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Drugs other than those listed here may also interact with oxacillin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

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Your pharmacist has additional information about oxacillin written for health professionals that you may read.

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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.