bumetanide

(byoo MEH tah nide)
Bumex

What is the most important information I should know about bumetanide?

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To reduce nighttime urination, take bumetanide early in the day unless otherwise directed by your doctor.

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Promptly report any muscle weakness or cramps to your doctor.

What is bumetanide?

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Bumetanide is in a class of drugs called loop diuretics (water pills). It decreases the amount of fluid in the body by increasing the amount of salt and water lost in the urine.

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Bumetanide is used to reduce swelling in the body caused by congestive heart failure, liver disease, or kidney disease.

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Bumetanide may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking bumetanide?

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Before taking bumetanide, tell your doctor if you have

an allergy to sulfa medicines such as sulfa-based antibiotics,

kidney disease,

liver disease,

diabetes mellitus,

gout, or

systemic lupus erythematosus.

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You may not be able to take bumetanide, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

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Bumetanide is in the FDA pregnancy category D. This means that bumetanide is known to be harmful to an unborn baby. Do not take bumetanide without first talking to your doctor if you are pregnant or could become pregnant during treatment.

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It is not known whether bumetanide passes into breast milk. Do not take bumetanide without first talking to your doctor if you are breast-feeding a baby.

How should I take bumetanide?

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Take bumetanide exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

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Take each dose with a full glass of water.

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To reduce nighttime urination, take bumetanide early in the day unless otherwise directed by your doctor.

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Do not stop taking bumetanide suddenly even if you feel better. Stopping suddenly could make your condition worse.

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It is important to take bumetanide regularly to get the most benefit.

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Your doctor may want you to have blood pressure monitoring or other medical evaluations during treatment with bumetanide to monitor progress and side effects.

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Store bumetanide at room temperature away from moisture and heat.

What happens if I miss a dose?

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Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and only take the next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if I overdose?

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Seek emergency medical attention if an overdose is suspected.

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Symptoms of a bumetanide overdose include weakness, muscle cramps, fatigue, dizziness, fainting, confusion, irregular pulse, nausea, and vomiting.

What should I avoid while taking bumetanide?

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Use alcohol cautiously. Alcohol may increase the side effects of bumetanide.

What are the possible side effects of bumetanide?

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If you experience any of the following serious side effects, stop taking bumetanide and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

muscle cramps or weakness;

an irregular heartbeat or fluttering in the chest;

abdominal pain or diarrhea;

low blood pressure (weakness, dizziness, fatigue); or

hearing loss.

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Other, less serious side effects may be more likely to occur. Continue to take bumetanide and talk to your doctor if you experience

dry mouth or increased thirst;

dizziness or lightheadedness;

constipation;

headache;

increased sensitivity to sunlight;

jaundice (yellow skin or eyes);

ringing in the ears;

nausea;

easy bleeding or bruising;

numbness in the hands or feet; or

a rash.

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Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect bumetanide?

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Before taking bumetanide tell your doctor if you are taking any of the following medications:

lithium (Lithobid, Eskalith, others);

probenecid (Benemid);

a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin), naproxen (Naprosyn, Anaprox, Aleve), ketoprofen (Orudis, Orudis KT, Oruvail), indomethacin (Indocin), diclofenac (Cataflam, Voltaren), etodolac (Lodine), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), tolmetin (Tolectin), fenoprofen (Nalfon), ketorolac (Toradol), or flurbiprofen (Ansaid); or

a diabetes medication such as glipizide (Glucotrol), glyburide (Micronase, Glynase, Diabeta), chlorpropamide (Diabinese), tolazamide (Tolinase), tolbutamide (Orinase), and others.

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You may not be able to take bumetanide, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medications listed above.

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Also, before taking bumetanide, tell your doctor if you are taking any other medicine to treat high blood pressure, water retention, heart problems, prostate problems, or another condition. Some medicines used to treat these conditions may interact with bumetanide and the effects on the heart may be increased.

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Drugs other than those listed here may also interact with bumetanide. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

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Your pharmacist has additional information about bumetanide written for health professionals that you may read.

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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.