methadone

(meh THAH dohn)
Dolophine, Methadose

What is the most important information I should know about methadone?

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When methadone is used as part of a treatment program for narcotic addiction maintenance or detoxification, it must be dispensed by a specially approved pharmacy.

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Use caution when driving, operating machinery, or performing other hazardous activities. Methadone may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

What is methadone?

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Methadone is a narcotic pain reliever, similar to morphine. Methadone also reduces withdrawal symptoms in people addicted to heroin or other narcotic drugs without causing the '"high" associated with the drug addiction.

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Methadone is used as a pain reliever and as part of drug addiction detoxification and maintenance programs.

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Methadone may also be used for purposes other than those listed here.

What should I discuss with my healthcare provider before taking methadone?

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Before taking methadone, talk to your doctor if you have

kidney disease;

liver disease;

asthma, lung disease, or breathing problems;

an enlarged prostate or difficulty urinating;

hypothyroidism;

seizures or epilepsy;

a head injury or brain tumor; or

Addison's disease.

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You may not be able to take methadone, or you may require a dosage adjustment or special monitoring during treatment.

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Do not take methadone without first talking to your doctor if you are pregnant or could become pregnant during treatment.

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Do not take methadone without first talking to your doctor if you are breast-feeding a baby.

How should I take methadone?

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Take methadone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

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When methadone is used as part of a treatment program for narcotic addiction maintenance or detoxification, it must be dispensed by a specially approved pharmacy.

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Methadone is available as tablets, liquid for oral administration, and as an injection. Oral forms of methadone must never be injected.

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Take the oral tablets with a full glass of water.

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To ensure that you get a correct dose, measure the liquid with a dose-measuring spoon, dropper, or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

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Your healthcare provider may recommend that methadone be administered by a family member, friend, or healthcare provider to ensure compliance with the treatment.

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Do not take more methadone than is prescribed. If you symptoms are not being adequately treated, contact your healthcare provider.

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It is important to take methadone regularly to get the most benefit.

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Additional forms of counseling and/or monitoring may be recommended during treatment with methadone.

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Methadone may be habit forming. Physical and/or psychological dependence can occur, and withdrawal effects are possible if the medication is stopped suddenly after prolonged or high-dose treatment. Do not stop taking methadone suddenly without first talking to your doctor if you have been taking it on a regular basis. Your healthcare provider may want to gradually reduce the dose.

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Store methadone at room temperature away from moisture and heat.

What happens if I miss a dose?

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Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of the medication.

What happens if I overdose?

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Seek emergency medical attention if an overdose of methadone is suspected.

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Symptoms of a methadone overdose may include shallow or decreased breathing, slow heart rate, small pupils, cold, clammy skin, coma, and death.

What should I avoid while using methadone?

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Do not take any prescription or over-the-counter medicine to treat a cold, cough, or pain while taking methadone without first talking to your doctor. These medicines may contain narcotics or alcohol.

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Do not use narcotic drugs or alcohol while taking methadone.

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Do not take more methadone than is prescribed. If you symptoms are not being adequately treated, contact your healthcare provider.

What are the possible side effects of methadone?

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If you experience any of the following serious side effects, stop taking methadone and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

difficulty breathing;

hallucinations or confusion;

chest pain;

fainting; or

loss of consciousness.

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Other, less serious side effects may be more likely to occur. Continue to take methadone and talk to your doctor if you experience

anxiety, nervousness, or restlessness;

dizziness or lightheadedness;

nausea, vomiting, or diarrhea;

drowsiness;

decreased appetite;

dry mouth;

constipation;

weakness; or

sexual problems.

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Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect methadone?

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Do not take methadone with any of the following drugs without first talking to your doctor:

a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate);

rifampin (Rifadin, Rimactane); or

a narcotic pain reliever such as buprenorphine (Buprenex, Subutrex), codeine (Tylenol with Codeine, others), hydrocodone (Lorcet, Lortab, Vicodin, Vicoprofen, others), hydromorphone (Dilaudid), levorphanol (Levo-Dromoran), meperidine (Demerol), morphine (Kadian, MS Contin, MSIR, OMS, Roxanol, Oramorph SR, others), oxycodone (M-Oxy, OxyContin, OxyIR, Roxicodone, Percocet, Percodan, others), oxymorphone (Numorphan), propoxyphene (Darvon, Darvocet, others), and others.

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You may not be able to take methadone, or you may require a dosage adjustment or special monitoring during treatment.

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Methadone may increase the effects of other drugs that cause drowsiness or dizziness, including antidepressants, alcohol, sedatives (used to treat insomnia), pain relievers, anxiety medicines, muscle relaxants, and antihistamines. Do not drink alcohol and do not take any medicine without first talking to your doctor while taking methadone.

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Drugs other than those listed here may also interact with methadone. Talk to your healthcare provider before taking any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

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Your pharmacist has additional information about methadone written for health professionals that you may read.

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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed

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Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.