If you mean calves like baby farm animals, no. If you mean calves like the backs of your legs, no. That is maybe a sign of blocked blood flow. Old folks often have that condition, but they usually know about it several years before it becomes a problem. If you are not old yet, you need to see a doctor before you have a stroke.
I've never heard of anyone complaining about fatigued calves. Cramps yes or better known as a charley horse but no one saying tired calves. I would ask my doctor or coach about it.
"You could be out for a run or drifting off to sleep when it happens: The muscles of your calf or foot suddenly become hard, tight, and painful. ... Sometimes called “charley horses” -- particularly when they're in the calf muscles – cramps are caused by muscle spasms – involuntary contractions of one or more muscles. Mar 31, 2017"